Erratum to: Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes
نویسندگان
چکیده
منابع مشابه
Erratum to: Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes
Identifying Hoxc8 target genes is at the crux of understanding the Hoxc8-mediated regulatory networks underlying its roles during development. However, identification of these genes remains difficult due to intrinsic factors of Hoxc8, such as low DNA binding specificity, context-dependent regulation, and unknown cofactors. Therefore, as an alternative, the present study attempted to test whethe...
متن کاملGenes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes
The subnetwork of Hoxc8 and its neighboring genes. The genes coexpressed with Hoxc8 were analyzed using the Ingenuity Pathway Analysis tool. Hoxc8 is a node of the subnetwork comprising Fzd2, Adam19, Ly6a, Pmp22, Serpinf1, and Pbx1. The collagen family genes are the neighboring genes
متن کاملThe identification of Hoxc8 target genes.
Hox genes encode transcription factors that control spatial patterning during embryogenesis. To date, downstream targets of Hox genes have proven difficult to identify. Here, we describe studies designed to identify target genes under the control of the murine transcription factor Hoxc8. We used a mouse 16,463 gene oligonucleotide microarray to identify mRNAs whose expression was altered by the...
متن کاملSponge Genes Provide New Insight into the Evolutionary Origin of the Neurogenic Circuit
The nerve cell is a eumetazoan (cnidarians and bilaterians) synapomorphy [1]; this cell type is absent in sponges, a more ancient phyletic lineage. Here, we demonstrate that despite lacking neurons, the sponge Amphimedon queenslandica expresses the Notch-Delta signaling system and a proneural basic helix loop helix (bHLH) gene in a manner that resembles the conserved molecular mechanisms of pri...
متن کاملActivated signal transduction kinases frequently occupy target genes.
Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules and Cells
سال: 2017
ISSN: 1016-8478,0219-1032
DOI: 10.14348/molcells.2017.1311